The activies of Iama,ilis in Esfahan began in the 3rd century A.H. The information on these activities is vague and ambiguous until the second half of the 5th century. Through these centuries, Ahmad Ibn-i Hosein, knomn as Dandan, and Abu Hatam Razi have been mentiomed to be connected with the Isma'ilis of this city in historical sources. The peak of Isma'ili activities was during the Seljuq era. Two well-known Isma'ili da'is (inviters) of the time, Abbolmalik Ibn-i Attash and his son, Ahmad, led the Isma'ilis in the Seljuq period. During Abdolmalik's leadership, Esfahan was the center of Isma'ili activities. While discussing the Isma'ili efforts in Esfahan, this article also deals with their relations with the Fatimids of Egypt, the Nizari Ismah'ilis of Alamut and the Hanafi and Shafi'i Sunnite scholars. At the end, there comes a list of the men assassinated by the Isma'ilis of Esfahan.